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- W2362865061 abstract "Aim Observing the effect of different doses of indomethacin on the implantation of mouse blastocyst to establishment mice model of blastocyst implantation dysfunction induced by indomethacin. Methods ①3.67 to 5mg·kg~-1 doses of indomethacin was administrated subcutaneously to adult Kunming mice weighed (30±2) g twice at 9:00 and 16:00 on day 3 and day 4 of pregnancy, and its effect on implantation rate and number of implanted blastocyst was observed to decide a best dose.② Dying rate, dying point by Evan's blue, concentration of 6-keto-PGF1α in endometrium of mice on pregnancy day 5 and uterus weight of mice on pregnancy day 8 was oberserved in model group and normal group. Results ① Implantation rate and number of implanted blastocyst decreased greatly by 4.33 mg·kg~-1 dose of indomethacin on mice (P0.01);implantation was completely obstructed by 5 mg·kg~-1 dose of indomethacin,4.33 mg·kg~-1 dose of indomethacin was selected to establishment mice model of blastocyst implantation dysfunction.② The uterus weight of mice on pregnancy day 8 , dying point by Evan's blue and concentration of 6-keto-PGF1α in endometrium of mice on pregnancy day 5 decreased very greatly(P0.01), dying rate by Evan's blue obviously decreased (P0.05) in model group than in normal group. Conclusion 4.33 mg·kg~-1 dose of indomethacin administrated subcutaneously on mice twice at 9:00 and 16:00 on day 3 and day 4 of pregnancy can be used to establish mice model of implantation dysfunction; Inhibition of local blood infiltration and deciduation may be the mechanism of its anti-implantation effect." @default.
- W2362865061 created "2016-06-24" @default.
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- W2362865061 date "2005-01-01" @default.
- W2362865061 modified "2023-09-23" @default.
- W2362865061 title "Establishment of mice model of blastocyst implantation dysfunction induced by indomethacin" @default.
- W2362865061 hasPublicationYear "2005" @default.
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