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- W2362865696 abstract "OBJECTIVE To investigate the effects of Brucea javanica Oil on apoptosis and vascular endothelial growth factor secretion of A549 cells and explore its mechanism of action.METHODS Percentage of apoptosis cells was evaluated by flow cytometry and VEGF secretion was determined by ELISA after cells were incubated with different concentrations of Brucea javanica oil(0.5,1.25,2.5,3.75 g·L-1)for 6,24 or 48 h.RESULTS It was found that percentage of apoptosis cells was significantly increased after cells were incubated with Brucea javanica oil(2.5,3.75 g·L-1) for more than 6 h.The fact that Brucea javanica oil(1.25 g·L-1) induced cells to apoptosis after incubated for 24 h or 48 h was observed in Annexin V staining method and DNA gel electrophoresis,but not in other methods.Furthermore,Brucea javanica oi(l2.5 g·L-1)significantly reduced VEGF secretion in A549 cells.CONCLUSION Brucea javanica oil induced apoptosis and reduced VEGF secretion of tumor cells,which might be one mechanism of Brucea javanica oil in treating pulmonary carcinosis." @default.
- W2362865696 created "2016-06-24" @default.
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- W2362865696 date "2009-01-01" @default.
- W2362865696 modified "2023-09-25" @default.
- W2362865696 title "Effect of Brucea javanica Oil on Apoptosis and Vascular Endothelial Growth Factor Secretion of A549 Cells" @default.
- W2362865696 hasPublicationYear "2009" @default.
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