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- W2362879527 abstract "Objective To explore the effects and underling mechanism of Scutellaria barbata D.Don extract(SBE) on cell apoptosis of human colon carcinoma cell lines SW480,LoVo and HT-29. Methods The cells of SW480,LoVo and HT-29 were cultured and treated by SBE,Medicine Kang Fuxin and nidus Vespae for 48 hours.The apoptosis and inhibitory rates and the change of cell cycle were evaluated by MTT assay and flow cytometry.The expressions of Bcl-2 and Caspase-3 were detected by RT-PCR. Results Compared to Medicine Kang Fuxin and nidus Vespae,the apoptosis and inhibitory rates of SW480,LoVo and HT-29 cells treated with different concentrations of SBE were increased in a dose-dependent manner(P0.01).The cells stayed at S stage were increased,the expression of Bcl-2 was reduced and Caspase-3 expression was increased in the SBE-treatead cells(P0.01).Conclusion SBE can induce apoptosis and inhibit proliferation of human colon carcinoma cell lines,which might be related to upregulating the expression of Caspase-3 and downregulating the expression of Bcl-2.The inhibitory effect of SBE is greater than that of the extracts of Medicine Kang Fuxin and nidus Vespae." @default.
- W2362879527 created "2016-06-24" @default.
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- W2362879527 date "2013-01-01" @default.
- W2362879527 modified "2023-09-28" @default.
- W2362879527 title "Effects of Scutellaria barbata D. Don extract on cell apoptosis of human colon carcinoma cell lines" @default.
- W2362879527 hasPublicationYear "2013" @default.
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