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- W2362883264 abstract "Objective:To evaluate the antibacterial activities of piperacillin/sulbactam(2∶1)in vivo.Method:Mice infection models were established by using beta-lactamase producing strains S.aureus,E.coli,K.pneumoniae and P.aeruginosa.The trial products including piperacillin,sulbactam,piperacillin/sulbactam(2∶1)and amoxicillin/sulbactam(2∶1)were given intravenously or subcutaneously.Results:Sulbactam,with ED 50 400mg/kg,provided little protection for infected mice.The ED 50 of piperacillin monotherapy intravenously for S.aureus,E.coli,K.pneumoniae and P.aeruginosa infected mice were 55.71mg/kg,6.54mg/kg,24.09mg/kg and 11.07mg/kg,respectively.That of piperacillin/sulbactam(2∶1)were 27.96mg/kg,2.49mg/kg,6.75mg/kg and 6.36mg/kg,respectively.The protection effects of combination were 2-,2.5-,3.5-and 1.8-fold than monotherapy.The ED 50 of piperacillin monotherapy subcutaneously for the 4 strains infected mice were 60.00mg/kg,9.14mg/kg,29.87mg/kg and 16.71mg/kg,respectively.That of piperacillin/sulbacrtam(2∶1)were 51.95mg/kg,4.41mg/kg,,8.19mg/kg, and 10.58mg/kg,respectively.The protection effects of combination were 1.2-,2-,3.6- and 1.5-fold than monotherapy.Conclusion:piperacillin/ sulbactam(2∶1)was more active than piperacillin monotherapy and amoxicillin/ sulbactam(2∶1)in treating infection models established by beta-lactamase producing strain.Intravenous injection is the optimal route for clinical use." @default.
- W2362883264 created "2016-06-24" @default.
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- W2362883264 date "2002-01-01" @default.
- W2362883264 modified "2023-09-22" @default.
- W2362883264 title "Study on the Antibacterial Activity of Piperacillin/Sulbactam(2∶1)in Vivo" @default.
- W2362883264 hasPublicationYear "2002" @default.
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