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- W2362885166 abstract "Objective To establish an accurate and reliable HPLC-UV method for determination of periplocin concentration in mouse plasma and apply to pharmacokinetic studies.Methods The mouse plasma spiked with digoxin as the internal standard was deproteinized by methanol,followed by solid-phase extraction with a C18 extraction cartridge,boasted the extracted solution with N2,and then redissolve with the mobile phase,finally injected this solution into the HPLC instrument for determination using a Agilent Zorbas SB-C18 column(150 mm× 4.6 mm,5μm) with acetonitrile-water(25∶75) as mobile phase,the flow rate was 1.0 mL/min,column temperaure was 25℃,and UV detection wavelength was 220 nm.Results There was no internal substance in plasma interfered with the determination of the samples.The linear range was between 0.02-2.0 mg/L(r=0.999 8),the lower limit quantization was 0.02 mg/L,the average recovery was more than 81.8%,the RSD of precision was less than 4.64%,and the accuracy was between 101.3%—111.7%.Conclusion This method is convenient,the result is accurate,and the sensitivity is higher.It could be successfully applied to determination of periplocin concentration in mouse plasma during its pharmacokinetic and bioavailability studies and providing scientific basis." @default.
- W2362885166 created "2016-06-24" @default.
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- W2362885166 date "2008-01-01" @default.
- W2362885166 modified "2023-09-27" @default.
- W2362885166 title "Determination of periplocin concentration in mouse plasma by HPLC" @default.
- W2362885166 hasPublicationYear "2008" @default.
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