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- W2362888485 abstract "Objective To investigate the relationship between Parkinson disease(PD) and trace elements,oxidative stress.Methods Fifty PD patients participated in the study,and 40 healthy volunteers were recruited as the control group.Trace elements,ceruloplasmin,copper oxidase,metallothionein,cupper/zinc‐superoxide dismutase,and malondialdehyde were tested.Results(1) Serum copper levels in patients with PD were significantly lower than those in the controls(P 0.01);serum zinc levels in patients of PD were significantly lower than those in the controls(P 0.01);serum plumbum levels in patients of PD were significantly higher than those in the controls(P 0.01).(2)The activity of cupper/zinc‐superoxide dismutase in patients of PD was significantly lower than that in the controls(P 0.01),and the concentration of malondialdehyde in patients of PD higher than that in the controls(P 0.05).Conclusions Copper and zinc deficiency may contribute to the pathogenesis of PD,and excess plumbum in the body may also be a risk factor of PD.The imbalance of the trace elements in the body,might lead to oxidative stress reaction,induce apoptosis and necrosis in the nerve cells,eventually lead to PD." @default.
- W2362888485 created "2016-06-24" @default.
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- W2362888485 date "2014-01-01" @default.
- W2362888485 modified "2023-09-28" @default.
- W2362888485 title "Trace elements and oxidative stress in Parkinson disease" @default.
- W2362888485 hasPublicationYear "2014" @default.
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