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- W2362891184 abstract "Objective To investigate the effects of antisense transforming growth factor-β1 on the factors related to metastasis in osteosarcoma.Methods The osteosarcoma cells were transfected by antisense TGF-β1 gene and selected by G418.Northern blot was used to detect the expression of MMP-2, MMP-9 and uPA mRNA in the transfected cells.Results The proliferation activity of Mv-1-Lu that were cultured in supernatant of transfected osteosarcoma cells was 0.975± 0.016 (control group 1.032± 0.027, P 0.05). The expression of MMP-2 and uPA mRNA in the transfected cells was decreased markedly.Conclusion To block the TGF-β1 autocrine loop of osteosarcoma cells through antisense gene technology could suppress the expression of MMP-2 and uPA,which can inhibit the invasion and metastasis of tumor." @default.
- W2362891184 created "2016-06-24" @default.
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- W2362891184 date "2005-01-01" @default.
- W2362891184 modified "2023-09-25" @default.
- W2362891184 title "Effects of antisense transforming growth factor-β1 on the factors related to metastasis in osteosarcoma" @default.
- W2362891184 hasPublicationYear "2005" @default.
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