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- W2362893242 abstract "Objective To study the relationship between vascular endothelial growth factor(VEGF),p53 protein expression and microvessel density (MVD) in papillary thyroid carcinoma with cervical lymph node metestasis.Methods 37 cases of papillary thyroid carcinoma were used to detect the enpression of VEGF and p53 protein and FⅧRAg by immunohistochemistry staining, and the relative level analysis was applied to deal the VEGF and p53 expression and MVD. Results In 37 cases,the positive expression rate of VEGF and p53 protein in papillary thyroid carcinoma were significantly higher than those of control groups( P 0.01). The positive expression rate of VEGF in cervical lymph node metastasis group was significantly higher than those of control group( P 0.05), but there was no signiticant difference of the positive expression rates of p53 protein between these two groups( P 0.05). The MVD of cervical lymph node metastasis group was significantly higher than those of control group( P 0.05). There was a significant positive correlation between VEGF positive expression rate and MVD (r=0.697, P 0.01), but there was no signiticant relationship between p53 protein expression and MVD( P 0.05). Conclusion VEGF expression in papillary thyroid carcinoma is related with cervical lymph node metastasis and along with its MVD. Finally, VEGF and MVD may be an important indicator in the prognosis behavior of papillary thyroid carcinoma." @default.
- W2362893242 created "2016-06-24" @default.
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- W2362893242 date "2004-01-01" @default.
- W2362893242 modified "2023-09-24" @default.
- W2362893242 title "Relationship between VEGF, p53 protein expression and microvessel density in papillary thyroid carcinoma" @default.
- W2362893242 hasPublicationYear "2004" @default.
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