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- W2362900932 abstract "Objective: To investigate the role of autocamtide-2-related inhibitory peptide(AIP),a highly specific inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKⅡ), in the induction and maintenance of long-term potentiation (LTP) of C-fiber evoked field potentials. Methods: Single square pulses (10-20 V,0.5 ms,1 min once) delivered to the sciatic nerve were used to evoke spinal field potentials. A conditioning tetanic stimulation (40 V,0.5 ms pulses at 100 Hz for 1 s repeated four times at 10 s intervals) was used to induce the spinal LTP. AIP was applied directly onto the recording segments of the spinal cord before and after LTP induction. Results: (1) AIP (200 μmol/L) , when applied 30 min before tetani,completely blocked LTP induction in all 6 rats tested. (2) AIP (200 μmol/L) reversed spinal LTP in a time-dependent manner: applied 30 min after LTP induction AIP depressed LTP in 7 rats,while applied 60 min after LTP induction,it depressed spinal LTP in 7 of 10 rats tested. The same concentration of AIP,applied at 3 h after LTP induction,however,did not affect spinal LTP in 6 rats. Conclusion: Activation of CaMK Ⅱ may be critical for the induction and the early-phase but not the later-phase maintenance of LTP of C-fiber evoked field potentials in spinal dorsal horn." @default.
- W2362900932 created "2016-06-24" @default.
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- W2362900932 date "2003-01-01" @default.
- W2362900932 modified "2023-09-24" @default.
- W2362900932 title "CaMK II inhibitor blocked the induction and early maintenance of LTP of C-fiber-evoked field potentials in spinal dorsal horn of adult rat" @default.
- W2362900932 hasPublicationYear "2003" @default.
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