Matches in SemOpenAlex for { <https://semopenalex.org/work/W2362905501> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2362905501 abstract "Objective To explore the potential protective effect in vivo of Edaravone,a free radical scavenger on model of acute lung injury in rats with sepsis.Methods Twenty-four male Wistar rats were randomly divided into three groups,ie.a control group(NS group),a model group(LPS group),a Edaravone treatment group(ED group).ALI was induced by injecting LPS intravenously(10 mg/kg) in the LPS group and the ED group.Meanwhile the ED group was intravenously injected with Edaravone(3 mg/kg).The NS group was injected with normal saline as control.The lung tissue samples were collected at 6 h after intravenous injection.The wet/dry(W/D) weight ratio of lung tissue was measured.The levels of myeloperoxidase(MPO),malondialdehyde(MDA) and superoxide dismutase(SOD) in lung tissue homogenate were assayed.The pathological changes and expression of nuclear factor-kappa B(NF-κB) in lung tissue were also studied.Results Compared with the NS group,The W/D,pathological scores,NF-κB expression,MPO and MDA levels in the LPS group were significantly higher(all P0.01),and the level of SOD was apparently lower(P0.01).The W/D,pathological scores,NF-κB expression,MPO and MDA levels in the ED group were significantly lower than those in the LPS group(all P0.01) and higher than those in the NS group(all P0.01).And the level of SOD in lung tissue of the ED group was higher than that in the LPS group and lower than that in the NS group(P0.01).Conclusions Edaravone has protective effect on ALI rat model.The mechanism may be related to its ability of clearing the reactive oxygen species,inhibiting the activation of the signal pathway of NF-κB and inflammatory cascade." @default.
- W2362905501 created "2016-06-24" @default.
- W2362905501 creator A5090095535 @default.
- W2362905501 date "2009-01-01" @default.
- W2362905501 modified "2023-09-27" @default.
- W2362905501 title "The Protective Effect of Edaravone on Acute Lung Injury of Rats with Sepsis" @default.
- W2362905501 hasPublicationYear "2009" @default.
- W2362905501 type Work @default.
- W2362905501 sameAs 2362905501 @default.
- W2362905501 citedByCount "0" @default.
- W2362905501 crossrefType "journal-article" @default.
- W2362905501 hasAuthorship W2362905501A5090095535 @default.
- W2362905501 hasConcept C126322002 @default.
- W2362905501 hasConcept C134018914 @default.
- W2362905501 hasConcept C142724271 @default.
- W2362905501 hasConcept C203014093 @default.
- W2362905501 hasConcept C203565725 @default.
- W2362905501 hasConcept C2775838275 @default.
- W2362905501 hasConcept C2776151105 @default.
- W2362905501 hasConcept C2776914184 @default.
- W2362905501 hasConcept C2777397205 @default.
- W2362905501 hasConcept C2777714996 @default.
- W2362905501 hasConcept C2777785397 @default.
- W2362905501 hasConcept C2778384902 @default.
- W2362905501 hasConcept C2778401633 @default.
- W2362905501 hasConcept C2779554857 @default.
- W2362905501 hasConcept C2780678043 @default.
- W2362905501 hasConcept C71924100 @default.
- W2362905501 hasConcept C90924648 @default.
- W2362905501 hasConcept C98274493 @default.
- W2362905501 hasConceptScore W2362905501C126322002 @default.
- W2362905501 hasConceptScore W2362905501C134018914 @default.
- W2362905501 hasConceptScore W2362905501C142724271 @default.
- W2362905501 hasConceptScore W2362905501C203014093 @default.
- W2362905501 hasConceptScore W2362905501C203565725 @default.
- W2362905501 hasConceptScore W2362905501C2775838275 @default.
- W2362905501 hasConceptScore W2362905501C2776151105 @default.
- W2362905501 hasConceptScore W2362905501C2776914184 @default.
- W2362905501 hasConceptScore W2362905501C2777397205 @default.
- W2362905501 hasConceptScore W2362905501C2777714996 @default.
- W2362905501 hasConceptScore W2362905501C2777785397 @default.
- W2362905501 hasConceptScore W2362905501C2778384902 @default.
- W2362905501 hasConceptScore W2362905501C2778401633 @default.
- W2362905501 hasConceptScore W2362905501C2779554857 @default.
- W2362905501 hasConceptScore W2362905501C2780678043 @default.
- W2362905501 hasConceptScore W2362905501C71924100 @default.
- W2362905501 hasConceptScore W2362905501C90924648 @default.
- W2362905501 hasConceptScore W2362905501C98274493 @default.
- W2362905501 hasLocation W23629055011 @default.
- W2362905501 hasOpenAccess W2362905501 @default.
- W2362905501 hasPrimaryLocation W23629055011 @default.
- W2362905501 hasRelatedWork W2349779310 @default.
- W2362905501 hasRelatedWork W2350040839 @default.
- W2362905501 hasRelatedWork W2351464807 @default.
- W2362905501 hasRelatedWork W2352634038 @default.
- W2362905501 hasRelatedWork W2354107154 @default.
- W2362905501 hasRelatedWork W2359340327 @default.
- W2362905501 hasRelatedWork W2362800819 @default.
- W2362905501 hasRelatedWork W2364254574 @default.
- W2362905501 hasRelatedWork W2364527086 @default.
- W2362905501 hasRelatedWork W2368700262 @default.
- W2362905501 hasRelatedWork W2374033058 @default.
- W2362905501 hasRelatedWork W2379120579 @default.
- W2362905501 hasRelatedWork W2393122611 @default.
- W2362905501 hasRelatedWork W2408815701 @default.
- W2362905501 hasRelatedWork W2464423946 @default.
- W2362905501 hasRelatedWork W3028914892 @default.
- W2362905501 hasRelatedWork W3029748869 @default.
- W2362905501 hasRelatedWork W3031106749 @default.
- W2362905501 hasRelatedWork W3032569841 @default.
- W2362905501 hasRelatedWork W3030773102 @default.
- W2362905501 isParatext "false" @default.
- W2362905501 isRetracted "false" @default.
- W2362905501 magId "2362905501" @default.
- W2362905501 workType "article" @default.