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- W2362907805 abstract "Objective:To investigate the analgesic effect and safety of epidural preemptive injection of ondansetron and morphine in the lower limb operation.Methods:80 ASAⅠ~Ⅱ patients aged 25 to 50 years old determined for lower limb operation under epidural combined anesthesia were divided into two groups radomly,with 40 cases in each group.In the group Ⅰ morphine 1.5 mg and ondansetron 2.0 mg were injected into epidural cavity at a time 20 minutes before operation,while the group Ⅱ was injected into the foregoing drugs just in the end of operation,and then connected with the analgesic pump fully.The dispensing of drugs in pump was as follows:morphine 4 mg,0.75% ropivacaine hydrochioride 150 mg and ondansetron 4 mg were put in 0.9% normal saline to 100 ml,the current velocity was 2 ml/h,PCA volume was 2 ml,the targeting time was 15 minutes.The VAS score,Ramsay score,comfortable score,total PCA volume and complication were recorded on the 4,12,24 and 28 hours after pump switch on respectively.Results:The VAS score in the group Ⅰ was significantly higher than that in the group Ⅱ(P0.05),the comfortable score in the group Ⅰ was also high compared with that in the group Ⅱ,but the total PCA volume in the group Ⅰ was obviously smaller than that in the group Ⅱ(P0.05).Conclusion:The epidural preemptive analgesia of ondansetron and morphine can enhance the analgesic effect in the lower limb operation,and does not increase complication." @default.
- W2362907805 created "2016-06-24" @default.
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- W2362907805 date "2008-01-01" @default.
- W2362907805 modified "2023-09-23" @default.
- W2362907805 title "Clinical effect of epidural preemptive analgesia of ondansetron and morphine in lower limb operation" @default.
- W2362907805 hasPublicationYear "2008" @default.
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