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- W2362927367 abstract "Objective To evaluate the clinical signification of hepatitis B virus large protein(HBV-LP) serum levels in the prediction of HBV DNA replication state and estimation of the efficacy of antivirus treatment.Methods Serum samples were collected from 90 patients with HBV infection.HBV-LP was examined using enzyme linked immunosorbent assay(ELISA).HBV DNA was quantitatively determined by real time polymerase chain reaction.The collected data were analyzed with bi-variate correlations method.Results There was no significant difference between the detectable rates of HBV DNA and HBVLP in 90 blood samples before treatment(P0.05);The levels of serum HBV-LP was positively correlated with HBV DNA copies(r=0.857,P=0.000)in total 210 blood samples.HBV-LP OD and HBV DNA replication decreased simultaneously with time following anti-viral treatment.Conclusion The levels of serum HBV-LP and the copies of HBV DNA decrease during the antivirus treatment,suggesting that serum HBV-LP can be used to estimate the state of HBV DNA replication and predict the effect of treatment." @default.
- W2362927367 created "2016-06-24" @default.
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- W2362927367 date "2009-01-01" @default.
- W2362927367 modified "2023-09-23" @default.
- W2362927367 title "Clinical application of serum hepatitis B virus large protein detection in patients with hepatitis B" @default.
- W2362927367 hasPublicationYear "2009" @default.
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