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- W2362938168 abstract "Objective To contrast the effect and safety of intracoronary adenosine with verapamil on slow-reflow phenomenon following percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). Methods 33 patients with ACS who developed slow-reflow phenomenon during PCI were divided into adenosine group (17 cases) and verapamil group (16 cases). Patients in adenosine group were given 3 mg adenosine intracoronary through guiding catheter and patients in verapamil group were given 2.5 mg verapamil. 1 min, 5 min and 10 min later coronary flow was assessed by the TIMI frame count method (TFC). And the changes of electrocardiogram and blood pressure were written down. Results Before the administration of intracoronary drugs, the TFC in adenosine group and verapamil group was 87.9±15.3 and 89.5±17.4. After the drugs were given, the TFC in adenosine group decreased to 58.5±13.4, 45.8±9.7, 50.2±11.6 and in verapamil group to 68.9±15.6, 59.7±14.5, 62.3±16.2 at first, 5th, 10th min respectively, TFC decreased greater in adenosine group than in verapamil group. Nine (53%) cases in adenosine group and 7 (44%) cases in verapamil group gained TIMI flow grade 3. Intracoronary administration of 2.5 mg verapamil can affect the heart rate and blood pressure more significantly than intracoronary administration of 3 mg adenosine. In hospital no death occur in both groups, during 6-month follow-up 29.4% (5 cases) patients in adenosine group and 43.8% (7 cases) in verapamil group developed major adverse cardiac events (MACE, including angina pectory, myocardia infarction, heart failure and death of heart disease), there is no statistical difference between two groups. Conclusion Both adenosine and verapamil can improve the coronary artery blood flow velocity in patients with ACS who developed slow-reflow phenomenon during PCI; compared with verapamil,adenosine is more effective and safer." @default.
- W2362938168 created "2016-06-24" @default.
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- W2362938168 date "2005-01-01" @default.
- W2362938168 modified "2023-09-22" @default.
- W2362938168 title "Effect and safety of intracoronary adenosine and verapamil on slow-reflow phenomenon following PCI in patients with acute coronary syndrome" @default.
- W2362938168 hasPublicationYear "2005" @default.
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