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- W2362938232 abstract "Objective: To evaluate the efficacy and safety of isotretinoin erythromycin gel united spironolactone in acne vulgaris. Method: 147 patients with the mild or moderate acne vulgaris were randomly divided into treatment group( n = 75)and control group( n = 72). They were topically treated with isotretinoin erythromycin gel once daily in the evening for 8 weeks,while the treatment group were treated with spironolactone,20mg was taken orally with the meal,3 times per day. And they were followed up on the 2,4,8 weeks after starting treatment. Result: The response rates of two groups were 20. 83% and 14. 29%respectively within 2 weeks after treatment,and there was no statistical significance( P 0. 05). The effectiveness rates for the treatment group( 54. 17%,80. 56%) were significantly higher than those in control group( 30. 00%,54. 29%) within 4 and 8 weeks respectively( P 0. 01). The drug related adverse reactions mainly is local irritation symptoms,and the incidence was31. 08%,29. 58% respectively,there was no statistically significant difference between the two groups. Conclusion: The treatment of isotretinoin erythromycin gel united spironolactone is effective,safe,with less adverse reaction and lower price,It's worth popularizing and applying in the mild or moderate acne vulgaris." @default.
- W2362938232 created "2016-06-24" @default.
- W2362938232 creator A5020119587 @default.
- W2362938232 date "2013-01-01" @default.
- W2362938232 modified "2023-09-28" @default.
- W2362938232 title "Clinical Study of Isotretinoin Erythromycin Gel Combined Spironolactone in the Treatment of Acne Vulgaris" @default.
- W2362938232 hasPublicationYear "2013" @default.
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