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- W2362938992 abstract "Objective To explore the activin A expression in rat experimental hepatic fibrosis induced by CCl 4 and analyse its role in the pathogenesis of hepatic fibrosis. Methods 24 male Sprague Dawley rats were randomly divided into the model group and control group. Hepatic fibrosis was induced in the model group rats (n=12) by subcutaneous injection of 40% carbon tetrachloride oily solution for a period of 7 weeks. A same amount of olive was injected in the control group (n=12). After carbon tetrachloride had been injected 7 weeks, all rats were killed. Activin βA expression was detected in the model and control group by immunohistochemistry. The activin βA messenger RNA transcription was assessed by semi-quantity reverse transcription polymerase chain reaction (RT-PCR). Results RT-PCR showed that the normal rat liver expressed activin βA mRNA slightly. After injection of carbon tetrachloride for 7 weeks, the mRNA level was significantly enhanced (P0.01). Immunohistochemistry showed activin A expression was enhanced in the fibrotic rat liver, and activin was localized in the hepatocytes of the normal or fibrotic rat liver. Conclusion Activin A expression is enhanced in hepatic fibrosis, and may be involved in the pathogenesis of hepatic fibrosis." @default.
- W2362938992 created "2016-06-24" @default.
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- W2362938992 date "2001-01-01" @default.
- W2362938992 modified "2023-09-25" @default.
- W2362938992 title "The Activin A Expression and Localization in Rat Hepatic Fibrosis Induced by CCl_4" @default.
- W2362938992 hasPublicationYear "2001" @default.
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