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- W2362942481 abstract "Objective To study the effect of basic fibroblast growth factor(bFGF) on the content of glutamic acid and aminobutyric acid in rat hippocampus following pentylenetetrazol-induced status epilepticus.Methods Postnatal day 60(P60) Sprague Dawley(SD) rats received pentetrazole(PTZ) intra-abdominaly to make the model of status epilepticus(SE).The rats were divided randomly into PTZ group、 PTZ + bFGF group、 normal saline(NS) group and NS + bFGF group.Each group was examined on the third day(d3),the seventh day(d7) and the fourteenth day(d14) after SE.The content of glutamic acid and aminobutyric acid(GABA) in homogenized brain tissue of the rats was detemined with high performance liquid chromatography.Results Content of glutamic acid was higher on d3,d7 and d14,especially higher on d14,after SE developed in PTZ group than that in NS group(P 0.01),the content of glutamic acid in PTZ + bFGF group was lower than that in PTZ group but was higher than that in NS group(P 0.05).Content of GABA also increased after sizure(P 0.05),while there was no significant difference between PTZ group and PTZ + bFGF group(P 0.05).Conclusions Content of both glutamic acid and GABA increased after SE developed for a period of time.bFGF can decrease the unusual increased content of glutamic acid in hippocampus." @default.
- W2362942481 created "2016-06-24" @default.
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- W2362942481 date "2009-01-01" @default.
- W2362942481 modified "2023-09-28" @default.
- W2362942481 title "Effects of basic fibroblast growth factor on the content of glutamic acid and aminobutyric acid in the hip-pocampus of rats following pentylenetetrazol-induced status epilepticus" @default.
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