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- W2362948427 abstract "Aim:To study the efficacy and safety of low-dose tacrolimus in the treatment of refractory generalized myasthenia gravis.Methods:5 cases of definitely diagnosed refractory generalized MG(Osserman ⅡB or MGFA ⅢB) were treated with FK-506(3 mg·d~(-1)) for 20 weeks.Clinical and safety assessments were evaluated at baseline and 4 weeks,8 weeks,12 weeks,16 weeks and 20 weeks after initial FK-506 administration.The FK-506 serum concentration was tested at 8～12 weeks after initial treatment.Results:All patients finished the 20 weeks treatment.One patient had transiently slight elevation of ALT and AST.However,no further side effect was found in these patients.At the end of treatment,all patients were found to have clinical improvement.MGFA,ADL and MMT were improved 38.1%～88.8%,48.4%～100% and 54.5%～91.3%,respectively.And the dosage of combined medications was also decreased.Conclusion:As a preliminary clinical study,lowdose tacrolimus was found effective and safety in the treatment of intractable generalized MG." @default.
- W2362948427 created "2016-06-24" @default.
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- W2362948427 date "2005-01-01" @default.
- W2362948427 modified "2023-09-27" @default.
- W2362948427 title "The Preliminary Clinical Study of Low-dose Tacrolimus in the Treatment of Refractory Generalized Myasthenia Gravis" @default.
- W2362948427 hasPublicationYear "2005" @default.
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