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- W2362950720 abstract "AIM To study the effect of calcineurin (CaN)-dependent sighing passway on proliferation of rat cardiac fibroblasts (FBs) uhder stimulation of angoitensin H (Ang Ⅱ ). METHODS Upon the model of cultured rat FBs, Ca2+ influx stimulated with Aug Ⅱ, CaN signaling pathway was blocked with cyclosporine A (CsA ) and Ca2+ channel with verapamil(Ver), detecting the activities of FBs CaN, mitogen activated protein kinase (MAPK) and protein kinase C(PKC), [3H]-leucine([3H]-Leu) and [3H]-thymidine([3H]-TdR) incorporation as the target to evaluate FBs Proliferation. RESULTS Synthesis rates of protein and nucleic acid stimulated by Ang Ⅱ in FBs increased significantly in contrast to control (P 0. 01 ); CsA and Ver markedly inhibited syntheses of protein and nucleic acid mediated by Ang Ⅱ in FBs with a significant difference from Ang Ⅱ stimulated group (P 0 .01 ). CsA and Ver also sup- pressed FBs on activity mediated by Ang Ⅱ, and Ver suppressed are PKC activity mediated by Ang Ⅱ. CONCLUSION The study indicates CaN signaling pathway play an important role in FBs prolifera- proliferation induced by Ang Ⅱ, but it is not the single signaling pathway in regulating FBs proliferation, MAPK-centered signaling pathway is also involved in FBs proliferation induced by Aug Ⅱ." @default.
- W2362950720 created "2016-06-24" @default.
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- W2362950720 date "2001-01-01" @default.
- W2362950720 modified "2023-09-23" @default.
- W2362950720 title "Signaling transconduction mediated cultured rat cardiac fibroblasts proliferation by angoitensin II" @default.
- W2362950720 hasPublicationYear "2001" @default.
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