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- W2362971853 abstract "AIM: To investigate the effect of LPS on tau hyper-phosphorylation in rat hippocampus.METHODS: After intraperitoneal injection of different doses of LPS,the changes of tau phosphorylation in rat hippocampus at different time points were detected.RESULTS: 1.Intraperitoneal injection of LPS resulted in a significant increase in total level of tau.2.tau was hyperphosphorylated at Ser396/404 at 8 h and 16 h,then dephosphorylated at 64 h after low dose injection of LPS(200 μg/kg BW),while tau was dephosphorylated at Ser199/202 by the same treatment.3.The phosphorylation status of tau at Ser396/404,Ser199/202 and Ser422 was not changed obviously with higher dose injection of LPS(2 mg/kg BW),and at this condition,hyperphosphorylation of tau at Ser214 was detected after 6 h and 24 h of the injection.CONCLUSION: Intraperitoneal injection of LPS influences tau phosphorylation in rat hippocampus at some sites seen in the brain of Alzheimer disease,implying that the involvement of inflammation is in the pathogenesis of Alzheimer's disease." @default.
- W2362971853 created "2016-06-24" @default.
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- W2362971853 date "2006-01-01" @default.
- W2362971853 modified "2023-09-24" @default.
- W2362971853 title "Effect of intraperitoneal injection of LPS on tau hyperphosphorylation in rat hippocampus" @default.
- W2362971853 hasPublicationYear "2006" @default.
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