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- W2362979587 abstract "Objective:To investigate the clinical significance of p53, C-erbB-2 and nm23 gene expression in non-small cell lung carcinoma(NSCLC).Methods:This research included the examination of p53, C-erbB-2 and nm23 gene expression by immunohistochemical technique in 89 cases of NSCLC tissue confirmed by histology or cytology and in 87 cases of normal lung tissue besides the carcinomatic tissue.Results:The positive rate of p53 and C-erbB-2 gene protein expression in the carcinomatic tissue is 60% and 67% respectively, which is higher than that in normal lung tissue (P0.05). The expression rate of nm23 gene protein in carcinomatic tissue, 67%, is significantly lower than that in the normal lung tissue (P0.05). The higher p53 gene protein expression is significantly connected with the pathology, primary tumor extension (T) and grade of differentiation (P0.05). While it is independent of gender, age, stage, lymph node metastasis (N), and remote metastasis (M). The C-erbB-2 gene protein expression is not associated with gender, age, histology, primary tumor extension (T) and grade of differentiation, stage, lymph node metastasis (N), or remote metastasis (M). The lower nm23 gene protein expression is only connected with lymph node metastasis (N),remote metastasis (M) and stage (P0.05), and is not connected with gender, age, histology, primary tumor extension (T) or grade of differentiation.Conclusion:The higher expression rate of p53 and lower expression rate nm23 gene protein in NSCLC carcinomatic tissue suggest their important role in the tumor generation, development, pathological characteristic and metastasis." @default.
- W2362979587 created "2016-06-24" @default.
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- W2362979587 date "2005-01-01" @default.
- W2362979587 modified "2023-09-28" @default.
- W2362979587 title "Clinical significance of p53, C-erbB-2 and nm23 protein expressed in non-small cell lung carcinoma" @default.
- W2362979587 hasPublicationYear "2005" @default.
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