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- W2362993415 abstract "Objective To study the protective effects of octreotide on hepatic ischemia-reperfusion(I-R) injury in the rabbits.Methods Twenty-four adult New Zealand rabbits were divided randomly and equally into 3 groups of octreotide preconditioning group(group T),I-R group(group R)and sham operative group(group C).The changes of MAP,HR were recorded before ischemia(T1),at 15 min(T2),30 min(T3) after ischemia,at 15 min(T4),30 min(T5),60 min(T6),120 min(T7),240 min(T8) after reperfusion.Serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),lactate dehydrogenase(LDH),endotoxin(ET) and plasma tumor necrosis factor(TNF)-α,interleukin(IL)-1β were detected at T1,T3,T5,T6,T7,T8.Results MAP and HR were lower in group R and T than those in group C,which were higher in group T than those in group R at T2-T6(P0.05).So did the changes of ALT,AST,LDH,ET,TNF-α and IL-1β(P0.05).Conclusion Octreotide can protect the liver from I-R injury in rabbits,which may be related to down-regulating inflammation medium TNFα,IL-1β and decreasing ET." @default.
- W2362993415 created "2016-06-24" @default.
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- W2362993415 date "2009-01-01" @default.
- W2362993415 modified "2023-09-23" @default.
- W2362993415 title "Protective effect of octreotide on hepatic ischemia-reperfusion injury in the rabbits" @default.
- W2362993415 hasPublicationYear "2009" @default.
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