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- W2362997320 abstract "Objective To study the expression of NF-κB and MMP-9 in the cultured HCC9204 cells transfected with inhibitoryκB vector and investigate the change of metastasis in HCC9204 cells. Methods Lipofectin method was used to transfect PcDNA3-IκB-αvector and PcDNA3 into the HCC9204 cells. Immunohistochemistry, western blotting and RT-PCR were employed to determine NF-icB and MMP-9 expression. Nuclear extracts were examined for NF-icB binding activity by EMSA. Laser scanning confocal microscopy (LSCM) was used to determine the location of MMP-9 and morphology of HCC9204 cells. Different cells going through PVPE membrane was used to determine the migration and invasion of the tumor cells. Results Lower NF-icB activity and less NF-κB and MMP-9 mRNA expression were found in pcDNA3-IκB-αtransfected cells. The morphology of the transfected cells and the location of MMP-9 protein changed. The capacity of invasion and metastasis of the transfected cells significantly decreased. Conclusions The expression of NF-κB is related to invasion and metastasis of HCC9204 cells. The inhibition of the activity of HCC9204 cells might be due to decrease in MMP-9 expression." @default.
- W2362997320 created "2016-06-24" @default.
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- W2362997320 date "2006-01-01" @default.
- W2362997320 modified "2023-09-25" @default.
- W2362997320 title "Relation of expression of NF-κB and MMP-9 to HCC metastasis" @default.
- W2362997320 hasPublicationYear "2006" @default.
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