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- W2363008220 abstract "Objective To study the inhibition of gigantol on aldose reductase and its mechanism.Methods We used ultra-violet(UV)spectrophotometry to detect the inhibition and types of inhibition,and used the molecular docking software Sybyl FlexX to predict the residues and the combining method of gigantol and aldose reductase.Results The 50 % inhibiting concentration(IC50)of gigantol on AR was 2.12 mmol/L,and the inhibition belonged to anti-competitive inhibition type in a dose-dependent manner.The residues of gigantol combining with aldose reductase were Trp111,His110,Tyr48,Trp20,the mainly binding mode being hydrophobic interaction,hydrogen bonding and Van der Waals force.Conclusion Gigantol exerts significant inhibition on aldose reductase activity." @default.
- W2363008220 created "2016-06-24" @default.
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- W2363008220 date "2011-01-01" @default.
- W2363008220 modified "2023-09-24" @default.
- W2363008220 title "Inhibition of Gigantol on Aldose Reductase and Its Mechanism" @default.
- W2363008220 hasPublicationYear "2011" @default.
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