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- W2363032703 abstract "Objective To determine the relative utility of 1H MRS and MRI for presurgical diagnosis of hippocampal sclerosis by the study on metabolic abnormalities and anatomical alterations in the brain of patients with temporal lobe epilepsy (TLE). Methods 1H MRS and MRI were performed on 8 patients with pathologically confirmed hippocampal sclerosis and 8 healthy volunteers on 2.0 T 1H MRS/MRI system. The values of NAA, Cr and Cho were calculated by integration of their peaks and the ratios of NAA/Cr, NAA/(Cr+Cho), and Cho/Cr were measured. The volumes of both hippocampal formations in every case were observed and the differences of hippocampal formation (DHF) were analyzed. Results The ratios of NAA/Cr, NAA/(Cr+Cho), and Cho/Cr in ipsilateral side were 0.55, 1.77, and 1.38, and in control subjects were 0.77, 1.38, and 1.06 separately. The ratios of NAA/Cr and NAA/(Cr+Cho) were decreased on ipsilateral side (t=2.15, 4.83 separately, P0.05), and the ratio of Cho/Cr was increased on ipsilateral side (t=2.34, P0.05). Based on the value of NAA/(Cr+Cho), six cases were lateralized with one case incorrect, and five cases showing bilateral abnormal. According to the value of DHF, two cases showed hippocampal atrophy. Therefore, by the combination of 1H MRS and MRI, seven of eight cases could be lateralized. Conclusion 1H MRS is sensitive to the diagnosis of neuron abnormality and coincident well with the pathological results. 1H MRS and MRI correctly lateralize most patients with hippocampal sclerosis and complement each other in final lateralization. The combination of 1H MRS and MRI can provide useful information for presurgical diagnosis of hippocampal sclerosis." @default.
- W2363032703 created "2016-06-24" @default.
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- W2363032703 date "2000-01-01" @default.
- W2363032703 modified "2023-09-27" @default.
- W2363032703 title "Studies on hippocampal sclerosis by ~1H MRS and MRI" @default.
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