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- W2363033870 abstract "Objective: To study the dynamic changes of C type natriuretic peptide(CNP) in plasma and aortic tissues and the effect of exogenous CNP on intima/media (I/M) ratios in a model of balloon injury of rat aorta Methods:CNP levels in plasma and aorta were determined by radioimmunoassay. CNP mRNA expression was measured by RT PCR technique. Results: CNP levels in plasma were significantly increased by 80.7% ( P 0.01), 43.5% ( P 0.05) and 27.5% ( P 0.05) 3 days, 10 days and 21 days after balloon injury, but its levels in aortic tissues were decreased by 46.6% ( P 0.05 ) on day 3 and increased by 2.8 ( P 0.01), 1.6 ( P 0.05) and 0.82 fold ( P 0.05) on day 10, day 21 and day 28 after balloon injury of rat aorta. In the meanwhile, CNP mRNA expression was also increased on day 10, day 21. Results also showed that the administration of CNP i.p. inhibited neointima formation. I/M ratios were decreased by 23%( P 0.05) and 20%( P 0.05) 7 days, and 21 days after balloon injury of rat aorta. Conclusion: CNP might be involved in the process of recovery after vascular endothelium denudation and exogenous CNP suppressed the neointima formation." @default.
- W2363033870 created "2016-06-24" @default.
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- W2363033870 date "1999-01-01" @default.
- W2363033870 modified "2023-09-25" @default.
- W2363033870 title "The role of C type natriuretic peptide in balloon injury of rat aorta" @default.
- W2363033870 hasPublicationYear "1999" @default.
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