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- W2363046207 abstract "OBJECTIVE To investigate the effect of Oridonin(SH-A), Xindonqnin A(SX-A), Ponicidin(SH-B) and Eriocalyxin B(ER-B) on angiogenesis in vitro. METHODS The effects of 4 compounds on angiogenesis in vitro were measured by the proliferation, migration and tube formation assay using ECV304 (human umbilical vein endothelial cell). RESULTS SH-A,SH-B,SX-A and ER-B had inhibitory effects on the proliferation of ECV304.Their IC50 to ECV304 were fell in the range of 1.47×10-5～3.76×10-5 mol·L-1,which showed similarity of inhibition. Four ent-Kaurenoids had different effects on the migration of ECV304 and their IC50 were in the range of 8.01×10-7～5.41×10-6 mol·L-1.SH-B was much stronger than the other three. All the four ent-Kaurenoids inhibited the tube formation with IC50 between 4.25×10-7～2.80×10-6 mol·L-1.SX-A was weaker than the other three. CONCLUSION Four ent-Kaurenoids could inhibit the migration and tube formation of ECV304 at lower concentrations,and they have no effect on the proliferation of ECV304." @default.
- W2363046207 created "2016-06-24" @default.
- W2363046207 creator A5065338783 @default.
- W2363046207 date "2007-01-01" @default.
- W2363046207 modified "2023-09-25" @default.
- W2363046207 title "Effect of Oridonin,Xindongnin A,Ponicidin,Eriocalyxin B on Human Angiogenesis in Vitro" @default.
- W2363046207 hasPublicationYear "2007" @default.
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