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- W2363048161 abstract "Objective:To investigate the effects of platelet-derived growth factor BB(PDGF-BB)on proliferation and calmodulin content in human vascular smooth muscle cells(hVSMCs).Methods:The hVSMCs were cultured;the effects of PDGF-BB on DNA synthesis and calmodulin content in hVSMCs were assayed at different time points and different concentra-tions by 3 H-TdR incorporation and phosphodiesterase in vitro.Results:The DNA synthesis of quiescent hVSMCs was pro-moted in a dose-dependent manner,with the maximal response at a PGDF-BB concentration of40ng/ml at36h.Calmodulin level was increased after hVSMCs proliferation and reached a peak at9h.The content of calmodulin increased in a dose-de-pendent manner,with the maximal response at a PGDF-BB concentration of30ng/ml.Conclusion:PDGF-BB can promote the proliferation of hVSMCs,which may be related to the calmodulin level. [" @default.
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- W2363048161 date "2004-01-01" @default.
- W2363048161 modified "2023-09-24" @default.
- W2363048161 title "Effects of platelet-derived growth factor BB on proliferation and calmodulin content in human vascular smooth muscle cells" @default.
- W2363048161 hasPublicationYear "2004" @default.
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