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- W2363053878 abstract "Objectives The present study was designed to investigated whether 308 nm excimer laser affects keratinocyte-derived factors cytokine by keratinocyte cultured. Methods Cultured keratinocyte was treated with various dosage of 308 nm excimer laser. The effects proliferation of keratinocyte by excimer laser were evaluated using CCK-8. ELISA was applied to evaluate the production of SCF,GM-CSF,bFGF in supernatant of HKC treated with excimer laser. Apoptosis was induced in HKC exposed to excimer laser. Results Proliferation of HKC was significantly reduced dosage-dependently with excimer laser. SCF,GM-CSF,bFGF secretion by HKC increased with increasing 308nm excimer laser(ranged100~300 mJ/cm2,which showed statistically difference to the control group(0 mJ/cm2). Secretion of those factor started after 6h of radiation. Exposure to excimer laser can induced apoptosis in HKC as assessed by DNA Ladder. Conclutions Our study provides in vitro demonstrating that HKC creates a favourable milieu through the secretion of some cytokine for melanocyte growth and migration." @default.
- W2363053878 created "2016-06-24" @default.
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- W2363053878 date "2008-01-01" @default.
- W2363053878 modified "2023-09-23" @default.
- W2363053878 title "308nm Excimer Laser Irradiation Up-regulates Keratinocyte-derived Cytokine" @default.
- W2363053878 hasPublicationYear "2008" @default.
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