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- W2363065343 abstract "Objective To explore the effect of norcantharidin(NCTD)on proliferation and apoptosis of implanted human pancreatic cancer in nude mice.Methods AsPC-1 cells of human pancreatic cancer were implanted subcutaneously into nude mice.Mice were randomly divided into control,5-FU,NCTD and NCTD+5-FU treatment groups.Tumor size,growth curve and inhibitory rate were evaluated.Cell cycle and apoptosis were measured.Morphological changes of tumor cells were observed.Results Tumor volume was diminished [(2.22±0.18)vs.(3.25±0.18)cm3,P0.01],tumor inhibitory rate was increased(31.69% vs.0.0%,P0.05).The increase in the percentage of the G2+M phase cells [(51.24±1.92)vs(23.31±1.81)%,P0.01)] and cell apoptosis rate [(0.23±0.05)% vs.(4.21±0.52)%,P0.01] in NCTD group was greater than that in control group.Compared with other groups,the difference in tumor volume,tumor inhibitory rate,percentage of the G2+M phase cells and cell apoptosis rate in NCTD+5-FU group was statistically significant(P0.01),with increased nuclear shrinkage,karyorrhexis and typical apoptosis.ConclusionNCTD inhibits the growth of implanted tumor of human pancreatic cancer in nude mice.The inhibitory effect could be intensified when combined with 5-FU." @default.
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- W2363065343 date "2007-01-01" @default.
- W2363065343 modified "2023-09-27" @default.
- W2363065343 title "The effect of norcantharidin on proliferation and apoptosis of transplanted human pancreatic cancer in nude mice" @default.
- W2363065343 hasPublicationYear "2007" @default.
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