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- W2363065845 abstract "Objective To explore the change of urinary Interleukin-18(IL-18) levels after coronary angiography(CAG)and percutaneous coronary intervention(PCI),and evaluate its predictive value in early diagnosis of Contrast-induced nephropathy(CIN). Methods The general clinical data of 180 patients were collected in patients who underwent coronary interventional procedure from the department of Cardiology,Affiliated Hospital of Xuzhou Medical College from March,2012 to September,2012. Before and 2 h,6 h,12 h,24 h,48 h urinary IL-18 samples were measured by using enzyme linked immune sorbent assay(ELISA) kits. 3d preoperative and postoperative within 24 h,48 h conducted venous blood3 ml were used to detect Scr. Results 1CIN was diagnosed in 16 of 180 patients,the incidence rate was 8. 9%. In CIN group,urinary IL-18 concentration increased after 2h of the procedure,but the difference was not significant preoperative differences(P 0. 05);after 6h,12 h,24h of the procedure,urine IL-18 levels rose significantly compared with the preoperative(P 0. 05);while the Scr level of 48 h after operation was a significant difference( P 0. 05). 2The area under the ROC curve of urinary IL-18 12 h after the operation was 0. 811,confidence interval of AUC 95% was(0. 735,0. 888). If the cutoff point of the diagnosis of CIN was 815. 61 pg /ml,the sensitivity was 87. 5% and the specificity was62. 2%. 3Analysis showed that preoperative,postoperative urinary IL-18 and serum creatinine was positively related to the single variable(P 0. 05). Conclusion Urinary IL-18 has good predictive value for the early diagnosis of CIN in patients with coronary interventional procedure." @default.
- W2363065845 created "2016-06-24" @default.
- W2363065845 creator A5091352412 @default.
- W2363065845 date "2014-01-01" @default.
- W2363065845 modified "2023-09-26" @default.
- W2363065845 title "Urine interleukin-18 as early indicator to predict contrast-induced nephropathyin patients undergoing PCI or CAG" @default.
- W2363065845 hasPublicationYear "2014" @default.
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