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- W2363073343 abstract "The interactions of two novel genistein esterified derivatives,genistein 7-acetylferulic acid ester(GenA)and genistein 7,4'-di-acetylferulic acid ester(GenDA),with calf thymus DNA(ctDNA)in Tris-HCl buffer(pH 7.2)were studied using UV-Vis spectroscopy and fluorescene spectroscopy.The decrease in the intensity of UV-Vis absorption and fluorescence spectra of GenA and GenDA were observed upon addition of ctDNA.The fluorescence of GenA and GenDA quenched by ctDNA may be mainly governed by static quenching mechanisms.The binding constants(KA)of GenA and GenDA with DNA at 293K were 2.81×106L·mol-1 and 1.19×104L·mol-1,respectively.Besides,studies on effects of I-,effects of ionic strength,DNA melting temperature and viscosity mesurements showed that there was a relatively strong interaction between GenA and ctDNA.The binding modes of GenA and GenDA with ctDNA were evaluated to be intercalative and groove binding,respectively." @default.
- W2363073343 created "2016-06-24" @default.
- W2363073343 creator A5048747742 @default.
- W2363073343 date "2010-01-01" @default.
- W2363073343 modified "2023-09-25" @default.
- W2363073343 title "Study on the Interactions of Genistein Esterified Derivatives with ctDNA" @default.
- W2363073343 hasPublicationYear "2010" @default.
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