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- W2363074819 abstract "AIM: To understand the effect of neutralizing anti-vascular endothelial growth factor (VEGF) antibody on the genesis of murine type Ⅱ collagen (COⅡ)-induced arthritis (CIA). METHODS: mice DBA/1J (8-10 weeks) were given intradermal injection chick tape Ⅱ collagen to set up the murine CIA model. The incidence of CIA and arthritis index were measured and the pathologic changes of articular tissue were observed after the injection of neutralizing anti-VEGF antibody. RESULTS: The anti-VEGF antibody could notably inhibit the genesis and severity of arthritis ((P0.05)) at the early stage of CIA formation; while it made no difference after CIA was completely formed. CONCLUSION: Anti-VEGF neutralizing antibody can significantly inhibit synovial fibroblast proliferation, neovascularization and angeitis genesis, which made it a promising agent for RA treatment." @default.
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- W2363074819 date "2005-11-01" @default.
- W2363074819 modified "2023-09-26" @default.
- W2363074819 title "[Effect of neutralizing anti-VEGF antibody on genesis of murine type II collagen-induced arthritis]." @default.
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