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- W2363089746 abstract "ObjectiveTo measure the markers for endothelial damages in type 2 diabetes mellitus with presence or absence of microalbuminuria, and study possible links between them. Methods 68 type 2 diabetic patients were divided into two groups:Ⅰgroup (normal albuminuria,n=30) and Ⅱ group (microalbuminuria,n=38) according to urinary albumin excretion rate (AER) at the beginning of the study. Meanwhile, 30 healthy adults were selected in control group (Ⅲ group,n=30). Circulating endothelial cells (CEC), plasma von Willebrand factor(vWF) and endothelin-1 (ET-1) were measured. The correlation between variables and AER were tested. Results The number of CEC and plasma levels of vWF and ET-1 elevated obviously in Ⅰand Ⅱ groups compared with Ⅲ group (P0.01), while increased variables in Ⅰgroup exceed Ⅱ group (P0.05), and were significantly correlated with AER (P0.01). Conclusion The generalized vascular endothelial damage precede to the development of microalbuminuria in type 2 diabetes mellitus. The levels of CEC, vWF and ET-1 are well correlate with AER, and may be predictive markers of diabetic nephropathy." @default.
- W2363089746 created "2016-06-24" @default.
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- W2363089746 date "2005-01-01" @default.
- W2363089746 modified "2023-09-23" @default.
- W2363089746 title "Measurements of the markers for endothelial damages and their links with urinary protein in patients with diabetes mellitus" @default.
- W2363089746 hasPublicationYear "2005" @default.
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