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- W2363117009 abstract "Objective:To demonstrate the role of phospholipase A 2 activity (PLA 2) on the apoptosis of neutrophiles. Methods:The effect of PLA 2 activity on neutrophil apoptosis was investigated by light, electron microscopy, DNA agarose electrophoresis and flow cytometry analysis. Results:The results showed that the apoptosis of neutrophiles was promoted by the treatment of 1 μg/ml LPS and 1 μm A 23187 , in 6 hours and 12 hours respectively. The apoptosis of neutrophil was markedly delayed by a PLA 2 inhibitor, 4 bromophanacyl bromid (p BPB 0.01～1 mM). Chloroquine, another PLA 2 inhibitor or SR 27417A , a PAF receptor antagonist, were found without such an effect as p BPB on neutrophil apoptosis. Conclusion: Results suggested that the neutrophile apoptosis may be promoted by phospholipase A 2 activation, but this process may not be related with PAF, one of the important metabolites of PLA 2." @default.
- W2363117009 created "2016-06-24" @default.
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- W2363117009 date "2000-01-01" @default.
- W2363117009 modified "2023-09-25" @default.
- W2363117009 title "Phospholipose A_2 Activation mediate neutrophil apoptosis" @default.
- W2363117009 hasPublicationYear "2000" @default.
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