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- W2363167053 abstract "Objective To study the pharmacokinetics of meropenem in the patients with continuous renal replacement therapy (CRRT).Meth- ods Each of 10 patients with CRRT was given a dose of 1000 mg of meropenem with iv during 30 min.Serum and displacement liquid sam- pies were collected.The concentrations of meropenem in serum and dis- placement liquid were measured.The software of 3P97 was used to deter- mine the pharmacokinetic parameters.Results Two-compartment mod- el was the best to describe the meropenem concentration-time relation when given intravenolisly.Pharmacokinetic parameters of meropenem in 10 patients with CRRT were follows:t_(1/2α) was (0.25±0.06) h,t_(1/2β)was (6.96±2.17) h,C_(max) was (48.50±12.32) mg·L~(-1),Vc was(24.48±7.21) L,AUC was (203.20±48.61) mg·h·L~(-1).Conclusion There was significant difference between the pharmacokinetic parameters of meropenem from the patients with CRRT and that from the normal vol- unteers.It is necessary to appropriate reduce dose or extend dosing inter- val in clinical use." @default.
- W2363167053 created "2016-06-24" @default.
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- W2363167053 date "2008-01-01" @default.
- W2363167053 modified "2023-09-25" @default.
- W2363167053 title "Pharmacokinetics of meropenem in patients with continuous renal replacement therapy" @default.
- W2363167053 hasPublicationYear "2008" @default.
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