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- W2363180834 abstract "Objective: To observe and discuss the influence of Garoderma lucidum spores on the cell factor IL-6 in the brain of epilepsy mouse.Methods: Thirty Wistar male mice at the age of 10 weeks : (150±10)g were divided into 3 groups at random(10 mice for each group): Garoderma lucidum spores group , epilepsy model group and blank contrast group. The sub-eclampsia dosage (32mg/kg ) of Pentetrazole(PTZ) was used in Garoderma lucidum spores group and epilepsy model group, once a day by abdominal cavity injection for 28 days, and one week after stopping injection, the test was done with PTZ of the same dosage, and the mouse that showing eclampsia of more than 2 grades 5 times in succession reached the “igniting” standard. use physiological saline of the same volume was used in blank contrast group by abdominal cavity injection. Garoderma lucidum spores group is given Garoderma lucidum spores to the stomach (prohibit to eat 6h before affusing) at the same time, the affusion volume to the stomach was1.0ml / time ; Epilepsy model group and blank contrast group were given physiological saline of the same volume. When Finished, putting The animals were killed when the experiment was finished,and mouse's brains were taken out rapidly in the low-temperature condition , and the change of IL-6 was measured by means of RIA. Result: We compared the Garoderma lucidum spores group with the epilepsy model group, the IL-6 in brain tissue reduced obviously (P0.05). Conclusion: Garoderma lucidum spores can effectively reduce the cell factor IL-6 in the brain of epilepsy mouse, correct the immunity dysfunction and play a role in anti-epilepsy." @default.
- W2363180834 created "2016-06-24" @default.
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- W2363180834 date "2005-01-01" @default.
- W2363180834 modified "2023-09-25" @default.
- W2363180834 title "The influence of Garoderma lucidum spores on the cell factor IL-6 in the brain of epilepsy mouse" @default.
- W2363180834 hasPublicationYear "2005" @default.
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