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- W2363209333 abstract "AIM: To investigate the effects of platelet-derived growth factor on DNA and collagen protein synthesis in human vascular fibroblasts. METHODS: In the present experiment, the human vascular fibroblasts were cultured and effects of platelet-derived growth factor-BB on DNA and collagen protein synthesis in human vascular fibroblasts were observed by using -TdR incorporation and -proline incorporation in vitro. RESULTS: Platelet-derived growth factor-BB significantly promoted NDA synthesis and collagen protein synthesis of quiescent human vascular fibroblasts, with a maximal response at a concentration of 30 μg·L -1 at 24 h and 36 h, respectively. CONCLUSION: Platelet-derived growth factor-BB promotes DNA and collagen protein synthesis in cultured human vascular fibroblasts.ollagenproteinsynthesisinhumanvascularfi broblastswereobservedbyusing [3 H]-TdRincorporationand [3 H]-prolineincorporationinvitro.RESULTS :Platelet-derivedgrowthfactor-BBsignificantlypromotedNDAsynthesisandcollagenproteinsynthesisofquiescenthu manvascularfibroblasts,withamaximalresponseataconcentrationof 3 0 μg·L-1at 2 4hand 3 6h,respectively.CONCLUSION :Platelet-derivedgrowthfactor-BBpromotesDNAandcollagenproteinsynthesisinculturedhumanvascularfibroblasts.[KEYWORDS] Platelet-derivedgrowthfactor;Fibroblasts;DN" @default.
- W2363209333 created "2016-06-24" @default.
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- W2363209333 date "2002-01-01" @default.
- W2363209333 modified "2023-09-25" @default.
- W2363209333 title "Effects of platelet-derived growth factor on DNA and collagen protein synthesis in human vascular fibroblasts" @default.
- W2363209333 hasPublicationYear "2002" @default.
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