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- W2363242104 abstract "Objective:To study the expressions of PGSK-3β、CEA and C-myc in non-small cell lung cancer(NSCLC) and evaluate their relationship with clinic pathological factors and the correlativity among these three indices.Methods:The expressions of PGSK-3β,CEA and C-myc were examined by immunohistochemical technique in 90 cases with NSCLC.Results:The positive rate of PGSK-3β in adenocarcinoma was significantly higher than in squamous cell lung cancer(P0.05).The positive rate of PGSK-3β of patients in clinical III-IV stage patients was significantly higher than that inⅠ-II stage(P0.05).The positive rate of CEA in peripheric lung cancer was significantly higher than that in central lung cancer(P0.01).The positive rate of CEA in the lung cancer with lymph node metastasis was significantly higher than that in the lung cancer without metastasis(P0.05).The positive rates of C-myc in the groups with moderate and poor differentiation were significantly higher than the group with well differentiation(P0.05).The high positive rate in lung cancer with moderate differentiation was significantly higher than that in poor differentiated and in well differentiated.Positive correlation was found between PGSK-3β and CEA in NSCLC(P0.05).Conclusion:PGSK-3β promotes the development of lung cancer,and is correlated with differentiation and clinical stage.The overexpression of CEA enhances heterogeneous adhesion in lung cancer,which facilitates its invasion and metastasis.The over expression of C-myc was a common molecular case.It was correlated with differentiation.The expressions of PGSK-3β and CEA is positively correlated in lung cancer." @default.
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- W2363242104 date "2009-01-01" @default.
- W2363242104 modified "2023-09-23" @default.
- W2363242104 title "Research on the Expressions of PGSK-3β,CEA and C-myc in Non-small Cell Lung Cancer and their Relationship" @default.
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