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- W2363251940 abstract "Objective: To observe the dynamic expression of tumor necrosis factor α (TNFα) and its effects on microglia activation of murine TNFα transgenic rats with cerebral ischemia. Meth- ods: By suture occlusion technique, the right middle cerebral artery in rat was occluded. Protein expression of TNFα and activation of microglia were examined by immunohistochemistry of TNFα and in-terginaM(OX42). The dynamic expression of TNFα and dynamic effects on microglia activation were observed in murine TNFα transgenic rats subjected to 1 hour occlusion and 3 hours, 12 hours, 24 hours, 72 hours and 7 days reperfusion. Results: TNFa overexpression at 3 hours after reperfusion in the is-chemic brain tissue of murine TNFα transgenic rats was observed and reached the peak. At 12 hours, 24 hours, 72 hours and 7 days reperfusion, TNFα overexpression decreased gradually. Microglia activation at 3 hours after reperfusion in the ischemic brain tissue of murine TNFα transgenic rats was observed and reached the peak. At 12 hours, 24 hours, 72 hours and 7 days reperfusion, microglia activation decreased gradually. Conclusion: The dynamic expression of TNFα accords with dynamic changes of microglia activation of murine TNFα transgenic rats with cerebral ischemia ,this suggests that the microglia activation is strongly related with overexpression of TNFα." @default.
- W2363251940 created "2016-06-24" @default.
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- W2363251940 date "2005-01-01" @default.
- W2363251940 modified "2023-09-28" @default.
- W2363251940 title "The dynamic expression of TNFα and dynamic effects on microglia activation of murine TNFα transgenic rats with cerebral ischemia" @default.
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