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- W2363257762 abstract "Objective:To study the effect of Shenshuai Yangzhen Jiaonang(Jiaonang)on the expressions of leptin and OBmRNA in rats with CRF-PD(chronic renal failure-peritoneal dialysis)and malnutrition.Methods:40 SD rats of either sex were fed with the forage with 0.5% adenine contained for 10w for the establishment of CRF models.Dialytic pipe was implanted and dialysis was underway for 2w,thus,CRF malnutrition rats were modeled.After successful modeling,3 groups were randomized,namely Jiaonang group,Shen Ling group and model control group.Additionally,normal control group(10 rats)was set up.Suspension irrigation was applied with corresponding drug administrated in each medicinal group and equal-dose physical saline was irrigated in control group.4w later after treatment,blood leptin level was tested.RT-PCR method was used to determine code leptin gene and OBmRNA expression.Results:After modeling,serum leptin and OBmRNA were up-leveled significantly in rats.Comparing with model group,after treated with Shenshuai Yangzhen Jiaonang and Shen Ling,the above indexes were reduced significantly(P0.01)and the effect of Shenshuai Yangzhen Jiaonang was superior to that of Shen Ling(P0.01).Conclusion:Shenshuai Yangzhen Jiaonang alleviates plasma leptin accumulation and down-regulates OBmRNA expression in CRF malnutrition rats." @default.
- W2363257762 created "2016-06-24" @default.
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- W2363257762 date "2008-01-01" @default.
- W2363257762 modified "2023-09-25" @default.
- W2363257762 title "Effect of Shenshuai Yangzhen Jiaonang on Expressions of Leptin and OB mRNA in CRF-PD Malnourished Rats" @default.
- W2363257762 hasPublicationYear "2008" @default.
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