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- W2363279498 abstract "To study of Rotenone cytotoxicity to human dopamimergic SH SY5Y cells. Human dopaminergic SH SY5Y cells were exposed to rotenone at the concentrations of 0 5, 0 75 or 1 00 μmol/L for 24 h, respectively. The mitochondrial potential was determined by incubating the cells with rhodamine 123, a mitochondrial specific dye, followed by laser scanning confocal microtechnique (LCSM) analyses of fluorescence signal. Every cell was obtained sixteenth fluorescence signal by scan and these signal were analyzed. Therefore, Rotenone treatment significantly decreased fluorescence signal as compared to controls, The fluorescence signal of high dose was 1.248 4±0.240 5, including middle dose(1 248 6±0 305 7), low dose(1 523 0±0 442 0), solvent group(1 770 1±0 391 9), control group(1 725 4±0 270 5). These data indicated a diminished mitochondrial membrane potential after rotenone treatment( P 0 05). The effects were rotenone concentration dependent.[Conclusion] These data confirmed that mitochondria may serve as one of the primary target for Rotenone cytotoxicity by altering the membrane potential." @default.
- W2363279498 created "2016-06-24" @default.
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- W2363279498 date "2003-01-01" @default.
- W2363279498 modified "2023-09-25" @default.
- W2363279498 title "The Study on Cytotoxicity of Rotenone to Human SH-SY5Y Cells in Vitro" @default.
- W2363279498 hasPublicationYear "2003" @default.
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