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- W2363305370 abstract "Objective To explore the mutations of BRCA1 and BRCA2 genes in sporadic breast cancer patients and their differences between breast cancer patients and healthy people.Methods Single strand conformation polymorphism (PCR-SSCP) was used to detect mutations of BRCA1(exons 5,11(11A and 11B) and 18) and BRCA2 (exon 11) genes in the blood samples from 83 sporadic breast cancer patients and 86 healthy people (as the normal control). RFLP (restriction fragment length polymorphism) was used for quantitative analysis of single nucleotide polymorphism for the basic site with single nucleotide polymorphism. Chi-squear test was used for qualitation data comparison.Results Single base changes on the base site of BRCA1 exons 5 [cDNA 273 and 287(C→G and A→T)],11[(2430,2532,2630,2685,3191,3232 and 3667,3876(T→C,T→C,T→G,T→C,C→G,A→G,A→G and C→A)],and 18 [5206 and 5214(T→A and C→T)] were found in some sporadic breast cancer patients and normal controls.The rate of BRCA1 gene mutation in the sporadic breast cancer patients was higer than in the normal controls (14.5% vs 2.3%,P0.05). RFLP showed that base site changes [cDNA 2430,2630(T→C,T→G)] was SNP; the distribution of the base site [2430 (T→C)] allele frequency was different between the sporadic breast cancer patients and the normal controls,but without statistical significance (P0.05).Conclusions BRCA1 gene mutation occurs more often in sporadic breast cancer,but BRCA2 gene mutation seldom happens." @default.
- W2363305370 created "2016-06-24" @default.
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- W2363305370 date "2009-01-01" @default.
- W2363305370 modified "2023-09-23" @default.
- W2363305370 title "Analysis of mutations of BRCA1 and BRCA2 genes in sporadic breast cancer patients" @default.
- W2363305370 hasPublicationYear "2009" @default.
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