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- W2363307576 abstract "Objective To investigate the selective modulation of toremifene on the bone and uterine tissue of menopausal rats.Methods Thirty female SD rats(12-months old) were randomized into three groups:menopause group (fed with distilled water 1 mL/d);estrogen group (fed with estradiol valerate 800 μg/kg·d);toremifene group(fed with toremifene 6 mg/kg·d).All rats were sacrificed 3 months later,the level of serum estradiol(E2) was determined and the gross weight of uterus were scaled.The lumbar and femoral bone mass density(BMD) were measured with the DEXA Bone Densitomor and the histologic parameters of the uterus were analyzed,including luminal epithelial thickness(μm),stromal thickness(μm),and cross-sectional area(mm2) with IMS automatic cell-image-analyzing system,and the expression of endometrial ER-α mRNA was determined by reverse transcription-polymerase chain reaction(RT-PCR).Results The gross weight and histologic parameters of the uterus except luminal epithelial thickness and the ER-α mRNA expression in toremifene group were significantly lower than those of the other two groups.No significant difference was found between the toremifene group and the estrogen group in the lumbar and femoral BMD.The lowest BMD was found in the menopause group.Conclusions Toremifene has estrogen-like effect on the bone tissue and anti-estrogen effect on the uterus and endometrium in menopausal rats.The anti-estrogen effect is related with the decreased ER-α mRNA expression and hormonal level of the body." @default.
- W2363307576 created "2016-06-24" @default.
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- W2363307576 date "2006-01-01" @default.
- W2363307576 modified "2023-09-23" @default.
- W2363307576 title "Elective modulation of toremifene on bone and uterine tissues of menopausal rats" @default.
- W2363307576 hasPublicationYear "2006" @default.
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