Matches in SemOpenAlex for { <https://semopenalex.org/work/W2363389598> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2363389598 endingPage "9" @default.
- W2363389598 startingPage "1135" @default.
- W2363389598 abstract "To compare the effects of different approaches to establishing rat models of acute liver failure (ALF).Sixty-eight Sprague-Dawley rats were randomly divided into 3 groups for establishing ALF models using 3 different approaches, namely conventional hepatectomy for resecting 90% liver tissue as described by Higgins and Anderson, modified bloodless hepatectomy for resecting 90% liver tissue, and intraperitoneal injections of 700 mg/kg D-galactosamine (D-gal) and 5 µg/kg lipopolysaccharide (LPS). The mortality of the rats due to postoperative bleeding and survival rate at 7 days after the surgery were recorded. The levels of alanine aminotransferase (ALT), total bilimbin (Tbil), albumin (ALB), NH3, glucose (Glu) and prothrombin time (PT) were monitored, and histopathologies of the liver were examined at 24 and 72 h after the surgery.The mortality rate due to postoperative bleeding was higher in conventional hepatectomy group than in the modified surgical group (15% vs 0). The survival rate at 7 days was 25%, 0%, 15% in conventional surgical group, modified surgical group and drug injection group, respectively. In the latter two groups, significant changes of ALT, Tbil, ALB, NH3, Glu, and PT were recorded at 24 and 72 h after the modeling (P<0.05), and these changes were the most obvious at 24 h in modified surgical group and at 72 h in the drug injection group; ALB in both groups declined to the lowest at 7 days and then increased gradually. Liver cell degeneration and necrosis were found in modified surgical group and drug injection group at 24 h and 72 h after the modeling.Both the modified 90% bloodless hepatectomy and injections of D-gal and LPS can be used to establish ideal rat models of ALF to suit different ALF-related researches." @default.
- W2363389598 created "2016-06-24" @default.
- W2363389598 creator A5008370090 @default.
- W2363389598 creator A5017167337 @default.
- W2363389598 creator A5020502173 @default.
- W2363389598 creator A5049248212 @default.
- W2363389598 creator A5057009461 @default.
- W2363389598 creator A5072232386 @default.
- W2363389598 creator A5079390192 @default.
- W2363389598 date "2014-07-01" @default.
- W2363389598 modified "2023-09-26" @default.
- W2363389598 title "[Establishment of a rat model of acute liver failure by a modified 90% bloodless hepatectomy and by D-galactosamine and lipopolysaccharide injection]." @default.
- W2363389598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25176081" @default.
- W2363389598 hasPublicationYear "2014" @default.
- W2363389598 type Work @default.
- W2363389598 sameAs 2363389598 @default.
- W2363389598 citedByCount "0" @default.
- W2363389598 crossrefType "journal-article" @default.
- W2363389598 hasAuthorship W2363389598A5008370090 @default.
- W2363389598 hasAuthorship W2363389598A5017167337 @default.
- W2363389598 hasAuthorship W2363389598A5020502173 @default.
- W2363389598 hasAuthorship W2363389598A5049248212 @default.
- W2363389598 hasAuthorship W2363389598A5057009461 @default.
- W2363389598 hasAuthorship W2363389598A5072232386 @default.
- W2363389598 hasAuthorship W2363389598A5079390192 @default.
- W2363389598 hasConcept C126322002 @default.
- W2363389598 hasConcept C141071460 @default.
- W2363389598 hasConcept C159110652 @default.
- W2363389598 hasConcept C185592680 @default.
- W2363389598 hasConcept C2776125364 @default.
- W2363389598 hasConcept C2776283816 @default.
- W2363389598 hasConcept C2776909242 @default.
- W2363389598 hasConcept C2778125326 @default.
- W2363389598 hasConcept C2778754761 @default.
- W2363389598 hasConcept C2780159080 @default.
- W2363389598 hasConcept C2780434524 @default.
- W2363389598 hasConcept C2781467277 @default.
- W2363389598 hasConcept C42219234 @default.
- W2363389598 hasConcept C503630168 @default.
- W2363389598 hasConcept C55493867 @default.
- W2363389598 hasConcept C71924100 @default.
- W2363389598 hasConcept C90924648 @default.
- W2363389598 hasConceptScore W2363389598C126322002 @default.
- W2363389598 hasConceptScore W2363389598C141071460 @default.
- W2363389598 hasConceptScore W2363389598C159110652 @default.
- W2363389598 hasConceptScore W2363389598C185592680 @default.
- W2363389598 hasConceptScore W2363389598C2776125364 @default.
- W2363389598 hasConceptScore W2363389598C2776283816 @default.
- W2363389598 hasConceptScore W2363389598C2776909242 @default.
- W2363389598 hasConceptScore W2363389598C2778125326 @default.
- W2363389598 hasConceptScore W2363389598C2778754761 @default.
- W2363389598 hasConceptScore W2363389598C2780159080 @default.
- W2363389598 hasConceptScore W2363389598C2780434524 @default.
- W2363389598 hasConceptScore W2363389598C2781467277 @default.
- W2363389598 hasConceptScore W2363389598C42219234 @default.
- W2363389598 hasConceptScore W2363389598C503630168 @default.
- W2363389598 hasConceptScore W2363389598C55493867 @default.
- W2363389598 hasConceptScore W2363389598C71924100 @default.
- W2363389598 hasConceptScore W2363389598C90924648 @default.
- W2363389598 hasIssue "8" @default.
- W2363389598 hasLocation W23633895981 @default.
- W2363389598 hasOpenAccess W2363389598 @default.
- W2363389598 hasPrimaryLocation W23633895981 @default.
- W2363389598 hasRelatedWork W1595868727 @default.
- W2363389598 hasRelatedWork W2312605145 @default.
- W2363389598 hasRelatedWork W2321368314 @default.
- W2363389598 hasRelatedWork W2361773251 @default.
- W2363389598 hasRelatedWork W2363389598 @default.
- W2363389598 hasRelatedWork W2371509256 @default.
- W2363389598 hasRelatedWork W2383701751 @default.
- W2363389598 hasRelatedWork W2586861912 @default.
- W2363389598 hasRelatedWork W3030708540 @default.
- W2363389598 hasRelatedWork W3200933799 @default.
- W2363389598 hasVolume "34" @default.
- W2363389598 isParatext "false" @default.
- W2363389598 isRetracted "false" @default.
- W2363389598 magId "2363389598" @default.
- W2363389598 workType "article" @default.