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- W2363391457 abstract "OBJECTIVE To study of the expres- sion and its clinical significance of p16 and proliferatingcell nuclear antigen(PCNA) in laryngeal squamous cellcarcinoma (LSCC). METHODS The expression of p16and PCNA were detected using immunohistochemistrymethod in tumor tissues of 40 patients with laryngealsquamous cell carcinoma. Their results were comparedto that in adjacent of cancer and normal tissues.RESULTS The positive expression rate of p16 in LSCCtissues was 50.0 % which was significantly lowerthan that in adjacent tissues (76.0 % ) and nor-mal tissues(100.0 %,P 0.05).The positive ex-pression rate of p16 in LSCC tissues of patients withpTNM Ⅰ,Ⅱ stages was significantly higher than that ofpatients with pTNM Ⅲ,Ⅳ stages(P 0.05).The posi-tive expression rate of PCNA in LSCC tissues was 55.0%which was significantly higher than that in adjacent tis-sues (32.0 %) and normal tissues(10.0 %)(P 0.05).The positive expression rate of PCNA in LSCC tissuesof patients with pTNM Ⅰ,Ⅱ stages was lower than thatof patients with pTNM Ⅲ,Ⅳ stages(P 0.05). The sur-vival times ≥ 5 years of patients with p16 positive andp16 negative was 66.7 % and 33.3 % respectively(P 0.05). The survival times ≥ 5 years of patients withPCNA positive and PCNA negative was 37.5 % and 62.5 %respectively(P 0.05). CONCLUSION p16 and PCNA wereindependent markers of progression and prognosis of pa-tients with LSCC. The p16 and PCNA detected together maybe more helpful to predict the prognosis of patients with LSCC." @default.
- W2363391457 created "2016-06-24" @default.
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- W2363391457 date "2005-01-01" @default.
- W2363391457 modified "2023-09-24" @default.
- W2363391457 title "Expression of p16 and PCNA in laryngeal squamous cell carcinoma" @default.
- W2363391457 hasPublicationYear "2005" @default.
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