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- W2363416241 abstract "Objective:To study the effect mechanism of curcumin in acute leukemia.Methods: HL60 cells were treated with curcumin at different concentrations(0.0,6.3,12.5和25.0 μmol/L).The methyl thiazolyltetrazolium assay was used to examine the effect of curcumin on growth of HL60 cells.DAPI staining and phase contrast microscope were used to examine the apoptosis status of HL60 cells.The cell cycle arrest and cell apoptosis were analyzed by flow cytometry.Results: Curcumin could inhibit the growth of HL60 cells in timeand dose-dependent manner.Curcumin(20.4 μmol/L)had 50% inhibitory rate on the growth of HL60 cells at 48 hours.After treatment with curcumin for 48 hours,the typical apoptosis was seen under phase contrast microscope and fluorescence microscope in 25.0 μmol/L group.Curcumin could arrest HL60 cells growth in S phase under 6.3,25.0 μmol/L,and in G2/M phase under 12.5 μmol/L.Conclusion:Curcumin can inhibit proliferation,cause S phase and G2/M phase arrest at different concentrations,and induce apoptosis of HL60 cells.The caspase 3 involves in apoptosis and cell cycle arrest of HL60 cells." @default.
- W2363416241 created "2016-06-24" @default.
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- W2363416241 date "2008-01-01" @default.
- W2363416241 modified "2023-09-23" @default.
- W2363416241 title "Effect Mechanism of Curcumin in Acute Leukemia" @default.
- W2363416241 hasPublicationYear "2008" @default.
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