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- W2363419265 abstract "Objective:To observe the protective effect of oxymatrine(OMT)against chronic cardiotoxicity induced by adriamy- cin(ADR).Methods:Twenty six rabbits were randomly devided into four groups.The ADR group(n=8)were injected with ADR (2mg/kg)via auricular vein once a week for 8 weeks to induce chronic heart injury.The ADR+OMT group(n=8)received intrave- neous injection of OMT 10mg/kg at 30 min before administration of ADR.The normal saline group(n=5)received the same volume of 0.9% saline alone and the OMT group(n=5)received intraveneous injection of OMT alone.Before administration and 3 weeks after drug therapy,a catheter was advanced through left carotid artery and left ventricle to measure heart rate(HR),left ventricular systolic pressure(LVSP),left ventricular end-diastolic pressure(LVEDP),and left ventricular injection fraction(LVEF).The serum was co- llected for determination of the activities of lactate dehydrogenase(LDH)and creatine kinase isoenzyme MB(CK-MB).The myocardial ultrastructure changes were observed by electron microscropy at 3 weeks after drug therapy.Results:Compared with ADR+OMT group,both LVSP and LVEF in ADR group were signi-ficantly decreased,but LVEDP and the activities of LDH and CK-MB were sig- nificantly increased.The difference between the two groups was significant.Pathological examination demonstrated the more severer da- mage of the myocardial uhrastructure in ADR group than ADR+OMT group.No adverse reaction and pathological changes were ob- served in OMT group.Conclusion:Oxymatrine protects heart against adriamycin-induced injury in rabbits." @default.
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- W2363419265 date "2007-01-01" @default.
- W2363419265 modified "2023-09-23" @default.
- W2363419265 title "The protective effects of oxymatrine against adriamycin-induced cardiotoxicity in rabbits" @default.
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