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- W2363419957 abstract "[Objective] To study the protective role of HSP70 against DNA damage caused by ultraviolet C. [Methods] A549 cells transfected by HSP70 gene were irradiated by different strength of Ultraviolet C(0, 10, 20, 40, 80 J/m2), with A549 cells as normal control and A549 cells trasfected by pcDNA3.0 vector as a blank control. HSP70 expression was detected using western-blot assay. DNA damage was detected using single cell gel electrophoresis(SCGE). [Results] The results showed that the levels of DNA damage increased with the increasing strength of Ultraviolet C in A549 and transfected A549 cells. The protection against UVC-induced DNA damage in cells with overexpressed HSP70 was observed at UVC dose 20J/m2 and 40J/m2. Compared with A549 cells, the values of the Olive tail moment in cells with overexpressed HSP70 decreased significantly(P 0.01). [Conclusion] These results suggested that overexpressed HSP70 may play a role in protecting A549 cells from DNA damage caused by UVC irradiation and that there is a threshold of protection of HSP70 from DNA damage by UVC irradiation." @default.
- W2363419957 created "2016-06-24" @default.
- W2363419957 creator A5039558767 @default.
- W2363419957 date "2007-01-01" @default.
- W2363419957 modified "2023-09-27" @default.
- W2363419957 title "Overexpression HSP70 Protects A549 Cells Against DNA Damage Caused by Ultraviolet C Irradiation" @default.
- W2363419957 hasPublicationYear "2007" @default.
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