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- W2363437216 abstract "Objective To investigate the effect and mechanism of early intervention with Fangxiaoyin Granules (Granules for preventing asthma) on airway inflammation in asthmatic mice.Methods Fifty healthy BALB/c mice were randomized into 5 groups,i.e.normal control group,asthma model group,Fangxiaoyin Granules small-dose group,Fangxiaoyin Granules large-dose group,and budesonide (BUD) group,with 10in each.The asthmatic models were established with ovalbumin (OVA) sensitization for inspiration.The Fangxiaoyin Granules small-dose group and large-dose group were given small-dose (500g/L crude medicine) and large-dose (2500g/L crude medicine) of Fangxiaoyin Granules respectively through gastric feeding from the first day of sensitization,once a day,0.4ml each time,26days in all.The normal control group and asthma model group were given normal saline in the equal amount through gastric feeding.The BUD group was given BUD solution (0.5g/L) for nasal dripping since the 23rd day under the ethyl ether inhalation anesthesia,0.01ml/day,for 3days.Forty-eight hours after the last inspiration,the mice were put to execution.The contents of serum interleukin-4 (IL-4),interleukin-5 (IL-5),interfer-on-γ (IFN-γ),and interleukin-12 (IL-12) were measured,and the eosinophils (EOS) infiltration in the lung and marrow EOS% were observed with photoelectric microscope.Results In the asthma model group,the HE dyeing of the lung tissues showed that there were massive inflammatory infiltration,mainly EOS and neutrophils;the marrow EOS%,serum IL-4/IFN-γratio,and IL-5/IL-12ratio were significantly increased in comparing with those of the normal control group (P0.01).In the Fangxiaoyin Granules large-dose group and BUD group,the marrow EOS% was significantly decreased,the airway and perivascular inflammatory infiltration was significantly inhibited,and serum IL-4/IFN-γratio and IL-5/IL-12ratio were significantly decreased,the difference between the two groups was not statistically significant (P0.05).Conclusion Fangxiaoyin Granules could effectively down-regulate serum IL-4/IFN-γratio and IL-5/IL-12ratio,decreasing the marrow EOS%,and inhibiting the airway inflammation mainly with EOS infiltration." @default.
- W2363437216 created "2016-06-24" @default.
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- W2363437216 date "2012-01-01" @default.
- W2363437216 modified "2023-09-25" @default.
- W2363437216 title "Effect of Early Intervention with Fangxiaoyin Granules on Eosinophils and Airway Inflammation in Asthmatic Mice" @default.
- W2363437216 hasPublicationYear "2012" @default.
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