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- W2363449992 abstract "Objective To investigate the role of tumor necrosis factor-alpha in the allograft rejection of rat penetrating keratoplasty.Methods Forty-four inbred rats received an allo or isogeneic graft,and half allograft rats were treated by subconjunctival injection of anti-TNF-α monoclonal antibody.The serum levels of TNF-α were measured and the expression of TNF-α mRNA in corneas were detected by using enzyme linked immunosorbent assay and reverse transcription PCR respectively at different time points after corneal transplantation.The changes of corneal histopathy were also observed with microscope.Results Examination of the syngeneic grafts showed thin corneas with moderate inflammatory reaction in the superficial stroma.In therapy group,the changes were similar to the syngeneic group in the early phase,and to the allogeneic group when the rejection reaction occurred.The serum levels of TNF-α in all rats elevated in the early stage after surgery,then decreased gradually to the normal on post-operative day 7 in isogeneic group,while increased sharply in allogeneic group.Anti-TNF-α mAb decreased the levels and made them increase later,but there was no significant difference between the therapy group and allogroup when the rejection occurred (P0.05).RT-PCR analysis revealed that TNF-α mRNA was present in allografts,while no TNF-α mRNA expression in isogeneic grafts and normal corneas.The group receiving anti- TNF-α mAb had a significant delay in corneal allograft rejection with mean survival time of 13.8±2.17 days vs 10.2±1.94 days for the control group (P0.01).Conclusions It is suggested that TNF-α plays an important role in the pathogenesis of corneal allograft rejection,sequential determination of serum TNF-α after operation may be of value in the prediction and diagnosis of acute rejection,and anti-TNF-α antibody therapy can prolong the allograft survival time." @default.
- W2363449992 created "2016-06-24" @default.
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- W2363449992 date "2004-01-01" @default.
- W2363449992 modified "2023-09-28" @default.
- W2363449992 title "Experimental Study of Tumor Necrosis Factor-alpha in the Rejection of Rat Corneal Transplantation" @default.
- W2363449992 hasPublicationYear "2004" @default.
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